Sod1m^129X1/SvJ
QTL Variant Detail

Summary

• QTL variant: Sod1m^129X1/SvJ
• Name: superoxide dismutase 1, soluble, modifier; 129X1/SvJ
• MGI ID: MGI:3617644
• QTL: Sod1m Location: Chr13:99739968-110699911 bp Genetic Position: Chr13, Syntenic

Variant origin

• Strain of Specimen: 129X1/SvJ

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:66226

G86R Sod1 is a mutated gene causing ALS in a FVB/N background. G86R Sod1 FVB/N mice were mated to mice of a mixed genetic background involving C57BL/6J and 129X1/SvJ. Pedigree analysis indicated that a number of offspring were protected from the effects of the mG86R mutation. These protected mice were from C57BL/6J and 129X1/SvJ backgrounds, which initiated a genome wide scan for genes that modify the effect of the mutation. A significant modifying effect in male animals was associated with mouse Chromosome 13 between markers D13Mit36 (53 cM) and D13Mit76 (61 cM) with a LOD score of 5.07 observed at marker D13Mit227 (59 cM). This locus is named Sodm1 (Superoxide dismutase 1, soluble, modifier). Linkage was also observed in female animals to a lesser degree (LOD=3.82). Potential candidate genes for Sod1m are Smn1 (54 cM), Birc1a (54 cM, formerly Naip), and Serf1 (53 cM).

References

• Original: J:66226 Kunst CB, et al., Genetic mapping of a mouse modifier gene that can prevent ALS onset. Genomics. 2000 Dec 1;70(2):181-9
• All: 1 reference(s)