Ssb^tm1Rjma
Targeted Allele Detail

Summary

• Symbol: Ssb^tm1Rjma
• Name: small RNA binding exonuclease protection factor La; targeted mutation 1, Richard J Maraia
• MGI ID: MGI:3617648
• Synonyms: La^-
• Gene: Ssb Location: Chr2:69691963-69702185 bp, + strand Genetic Position: Chr2, 40.95 cM
• Alliance: Ssb^tm1Rjma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105552
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace exons 1 and 2 with a neomycin resistance cassette. Expression of transcript was shown to be lower in heterozygous mice than in wild-type mice. (J:105552)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssb Mutation: 32 strains or lines available

References

• Original: J:105552 Park JM, et al., The multifunctional RNA-binding protein La is required for mouse development and for the establishment of embryonic stem cells. Mol Cell Biol. 2006 Feb;26(4):1445-51
• All: 3 reference(s)