Rad54b^tm1Roka
Targeted Allele Detail

Summary

• Symbol: Rad54b^tm1Roka
• Name: RAD54 homolog B (S. cerevisiae); targeted mutation 1, Roland Kanaar
• MGI ID: MGI:3617695
• Synonyms: mRad54B^-
• Gene: Rad54b Location: Chr4:11558930-11615806 bp, + strand Genetic Position: Chr4, 5.11 cM
• Alliance: Rad54b^tm1Roka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105544
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to remove exons 12 and 13, including 28 highly conserved amino acids spanning the last conserved SNF2/SWI2 family member motif, by replacement with a neomycin resistance cassette. Northern blot confirmed ablation of transcription in mutant mice. (J:105544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rad54b Mutation: 143 strains or lines available

References

• Original: J:105544 Wesoly J, et al., Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Mol Cell Biol. 2006 Feb;26(3):976-89
• All: 5 reference(s)