Cebpa^tm1Btp
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Btp
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Bo Torben Porse
• MGI ID: MGI:3617752
• Synonyms: C/EBPalpha^deltaPHR
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Btp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105554
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Amino acids 180-194 were removed via homologous recombination. Expression of the mutant was comparable to wild-type. (J:105554)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 19 strains or lines available

References

• Original: J:105554 Porse BT, et al., The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo. Mol Cell Biol. 2006 Feb;26(3):1028-37
• All: 1 reference(s)