Tgif1^tm1Dwot
Targeted Allele Detail

Summary

• Symbol: Tgif1^tm1Dwot
• Name: TGFB-induced factor homeobox 1; targeted mutation 1, David Wotton
• MGI ID: MGI:3617788
• Synonyms: Tgif^-
• Gene: Tgif1 Location: Chr17:71151200-71160527 bp, - strand Genetic Position: Chr17, 41.87 cM
• Alliance: Tgif1^tm1Dwot page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105576
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Most of the second and third exons were removed and the GFP coding sequence was fused in-frame to codon 9. Northern blot failed to detect transcript in mutants. GFP was observed in a reciprocal expression pattern. (J:105576)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tgif1 Mutation: 52 strains or lines available

References

• Original: J:105576 Bartholin L, et al., TGIF inhibits retinoid signaling. Mol Cell Biol. 2006 Feb;26(3):990-1001
• All: 8 reference(s)