Chm^tm1Seab
Targeted Allele Detail

Summary

• Symbol: Chm^tm1Seab
• Name: CHM Rab escort protein; targeted mutation 1, Miguel C Seabra
• MGI ID: MGI:3617902
• Synonyms: Chm^3lox
• Gene: Chm Location: ChrX:111950290-112095214 bp, - strand Genetic Position: ChrX, 48.94 cM
• Alliance: Chm^tm1Seab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105458
• Parent Cell Line: GSI-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites around exon 4. A neomycin and a spectinomycin cassette with an additional loxP site were inserted into intron 4. Deletion of exon 4 would cause a frame shift, resulting in a premature stop codon. (J:105458)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Chm Mutation: 14 strains or lines available

References

• Original: J:105458 Tolmachova T, et al., Independent degeneration of photoreceptors and retinal pigment epithelium in conditional knockout mouse models of choroideremia. J Clin Invest. 2006 Feb;116(2):386-94
• All: 4 reference(s)