Rr27^tm4Msb
Targeted Allele Detail

Summary

• Symbol: Rr27^tm4Msb
• Name: regulatory region 27; targeted mutation 4, Marisa S Bartolomei
• MGI ID: MGI:3617971
• Synonyms: H19^{delta3.8kb-5'H19}, H19^tm5Msb
• Gene: Rr27 Location: unknown Genetic Position: Chr7, Syntenic
• Alliance: Rr27^tm4Msb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106218
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The targeting vector replaced 3.8 kb of sequence including the entire DMD and G-rich repeat element. Cre-mediated recombination removed the floxed neomycin resistance gene cassette. (J:106218)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rr27 Mutation: 7 strains or lines available

References

• Original: J:106218 Thorvaldsen JL, et al., Analysis of sequence upstream of the endogenous H19 gene reveals elements both essential and dispensable for imprinting. Mol Cell Biol. 2002 Apr;22(8):2450-62
• All: 5 reference(s)