Vezt^tm1.1Smc
Targeted Allele Detail

Summary

• Symbol: Vezt^tm1.1Smc
• Name: vezatin, adherens junctions transmembrane protein; targeted mutation 1.1, Marie C Simmler
• MGI ID: MGI:3618234
• Synonyms: Vezt^dfl
• Gene: Vezt Location: Chr10:93797384-93871661 bp, - strand Genetic Position: Chr10, 48.72 cM
• Alliance: Vezt^tm1.1Smc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121686
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This mutation was generated by cre-mediated deletion of both exon 5 and the neomycin selection cassette from the floxed Vezt^tm1Smc allele. Presence of the same two major bands on immunoblots of brain and testis protein extracts from wild-type and heterozygous mutant mice indicates absence of a protein product from the mutant allele; these bands are twice as intense for wild-type as for mutant samples. (J:121686)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Vezt Mutation: 36 strains or lines available

References

• Original: J:121686 Hyenne V, et al., Conditional knock-out reveals that zygotic vezatin-null mouse embryos die at implantation. Mech Dev. 2007 Jul;124(6):449-62
• All: 3 reference(s)