Supt20^drey
Chemically induced Allele Detail

Summary

• Symbol: Supt20^drey
• Name: SPT20 SAGA complex component; droopy eye
• MGI ID: MGI:3618352
• Gene: Supt20 Location: Chr3:54600228-54636187 bp, + strand Genetic Position: Chr3, 25.59 cM, cytoband D
• Alliance: Supt20^drey page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation comprises a T to C transition in the splice donor consensus sequence at the 3' end of exon 14, which results in aberrant splicing of most transcripts; a small quantity of wild-type transcript is produced. (J:106348)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Supt20 Mutation: 41 strains or lines available

Notes

The homozygous phenotype shows the same variability on a mixed C57BL/6J and C3H/HeJ background as after 10 generations of backcrossing onto C3H/HeJ. This may be due to the low level of wild-type transcript produced.

References

• Original: J:106348 Zohn IE, et al., p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation. Cell. 2006 Jun 2;125(5):957-69
• All: 2 reference(s)