Lims2^tm1.1Ref
Targeted Allele Detail

Summary

• Symbol: Lims2^tm1.1Ref
• Name: LIM and senescent cell antigen like domains 2; targeted mutation 1.1, Reinhard Fassler
• MGI ID: MGI:3618381
• Synonyms: Pinch2^-
• Gene: Lims2 Location: Chr18:32055346-32091673 bp, + strand Genetic Position: Chr18, 17.89 cM
• Alliance: Lims2^tm1.1Ref page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105248
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated excision of exons 3 and 4 caused a frame shift within the first LIM domain and should result in the expression of a short, non-functional N-terminal polypeptide. Northern blot, and Western blot failed to detect transcript and protein, respectively, in mutants. (J:105248)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lims2 Mutation: 20 strains or lines available

References

• Original: J:105248 Stanchi F, et al., Consequences of loss of PINCH2 expression in mice. J Cell Sci. 2005 Dec 15;118(Pt 24):5899-910
• All: 1 reference(s)