Crebbp^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Crebbp^tm1Jvd
• Name: CREB binding protein; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:3618462
• Synonyms: CBP^flox
• Gene: Crebbp Location: Chr16:3899198-4031864 bp, - strand Genetic Position: Chr16, 2.4 cM
• Alliance: Crebbp^tm1Jvd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88323
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP recombination site was inserted in intron 8 and a floxed Neo-HSV tk selection cassette was inserted in intron 9. The selection cassette was then removed from correctly targeted ES cells by by transient expression of cre recombinase. (J:88323)

Expression

In Mice Carrying this Mutation:	4 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Crebbp Mutation: 100 strains or lines available

References

• Original: J:88323 Kang-Decker N, et al., Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004 Feb;5(2):177-89
• All: 38 reference(s)