Aars1^sti
Spontaneous Allele Detail

Summary

• Symbol: Aars1^sti
• Name: alanyl-tRNA synthetase 1; sticky
• MGI ID: MGI:3618596
• Synonyms: Aars^A734E
• Gene: Aars1 Location: Chr8:111759781-111784237 bp, + strand Genetic Position: Chr8, 57.9 cM
• Alliance: Aars1^sti page

Aars1^sti/ Aars1^sti

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: Laboratory stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A C-to-A nucelotide change at coding nucleotide 2201 is predicted to result in an alanine to glutamic acid non-conservative amino acid change in codon 734 of the encoded protein. Transgenic rescue experiments using a wild-type Aars gene indicated that this transversion mutation is responsible for the mutant phenotype. (J:110647)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aars1 Mutation: 69 strains or lines available

Notes

The sticky mutation arose on an unknown mouse stock.

References

• Original: J:110647 Lee JW, et al., Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature. 2006;443(7107):50-5
• All: 7 reference(s)