Gck^Sgrd
Chemically induced Allele Detail

Summary

• Symbol: Gck^Sgrd
• Name: glucokinase; sugar daddy
• MGI ID: MGI:3618626
• Synonyms: GCK^K140E
• Gene: Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
• Alliance: Gck^Sgrd page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Chemically induced (ENU) Mutation: Single point mutation Mutation details: ENU mutagenesis induced an A to G substitution that results in the amino acid substitution of glutamine for lysine at position 140 (K140E). Western blot analysis confirmed reduced protein expression in the liver. (J:196563) Inheritance: Semidominant

Location of the ENU Gck^Sgrd mutation

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gck Mutation: 63 strains or lines available

References

• Original: J:196563 Fenner D, et al., Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators. J Biol Chem. 2011 Nov 11;286(45):39560-72
• All: 1 reference(s)