Tg(CAG-cre/Esr1*)86Lbgn
Transgene Detail

Summary

• Symbol: Tg(CAG-cre/Esr1*)86Lbgn
• Name: transgene insertion 86, Laurence Bugeon
• MGI ID: MGI:3618929
• Synonyms: BetaMCM86, Tg(ACTB-cre)86Lbgn, Tg(CAG-cre)86Lbgn, Tg(CAG-cre/ERT)86Lbgn
• Transgene: Tg(CAG-cre/Esr1*)86Lbgn Location: unknown
• Alliance: Tg(CAG-cre/Esr1*)86Lbgn page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F1

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(CAG-cre/Esr1*)86Lbgn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: This transgene expresses cre recombinase as a fusion protein with two copies of a tamoxifen-responsive estrogen receptor under the control of the CMV enhancer/ chicken beta-actin promoter. Expression was detected in a patchy pattern, with the highest levels of expression in skeletal and heart muscle tissue. In kidneys, cre is expressed in the nucleus of podocytes. (J:106338)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	CAG (chicken) Summary of all recombinase alleles driven by CAG.

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:106338 Bugeon L, et al., Inducible gene silencing in podocytes: a new tool for studying glomerular function. J Am Soc Nephrol. 2003 Mar;14(3):786-91
• All: 4 reference(s)