Fgfr1^tm3Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm3Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 3, Philippe Soriano
• MGI ID: MGI:3619011
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm3Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105920
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Intragenic deletion
• Mutation details: Deletion of nucleotides 1276-1356, encoding amino acids 407-433, resulted in the ablation of the Frs binding site without disrupting the alternative splicing of exons encoding the extracellular domain. (J:105920)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:105920 Hoch RV, et al., Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development. 2006 Feb;133(4):663-73
• All: 3 reference(s)