Ccng1^tm1Sst
Targeted Allele Detail

Summary

• Symbol: Ccng1^tm1Sst
• Name: cyclin G1; targeted mutation 1, Snorri S Thorgeirsson
• MGI ID: MGI:3619024
• Gene: Ccng1 Location: Chr11:40639379-40646044 bp, - strand Genetic Position: Chr11, 24.42 cM, cytoband B1.1
• Alliance: Ccng1^tm1Sst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106007
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo resulted in the deletion of 1.3-kb consisting of 199 bp of exon 1, all of intron 1 and 168 bp of exon 2. The deleted sequence included the ATG and most of the cyclin box motif. Northern blot confirmed absence of transcript in mutant livers. (J:106007)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccng1 Mutation: 20 strains or lines available

References

• Original: J:106007 Jensen MR, et al., Reduced hepatic tumor incidence in cyclin G1-deficient mice. Hepatology. 2003 Apr;37(4):862-70
• All: 3 reference(s)