Cdc42^tm1Brak
Targeted Allele Detail

Summary

• Symbol: Cdc42^tm1Brak
• Name: cell division cycle 42; targeted mutation 1, Cord Brakebusch
• MGI ID: MGI:3619134
• Synonyms: Cdc42^fl, Cdc42flox
• Gene: Cdc42 Location: Chr4:137047011-137085007 bp, - strand Genetic Position: Chr4, 69.83 cM
• Alliance: Cdc42^tm1Brak page

Kidney abnormalities in Cdc42^tm1Brak/Cdc42^tm1Brak Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105811
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 2 was flanked with loxP sites via homologous recombination. (J:105811)

Disease models

Expression

In Mice Carrying this Mutation:	126 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cdc42^tm1Brak

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc42 Mutation: 45 strains or lines available

References

• Original: J:105811 Wu X, et al., Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev. 2006 Mar 1;20(5):571-85
• All: 51 reference(s)