Tbx1^tm2.2Bem
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm2.2Bem
• Name: T-box 1; targeted mutation 2.2, Bernice E Morrow
• MGI ID: MGI:3619150
• Synonyms: Tbx1-, Tbx1^tm1.2Bem
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm2.2Bem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105980
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Exons 2 and 3 were removed via cre-mediated excision. The ATG is in exon 2. (J:105980)

Disease models

Expression

In Mice Carrying this Mutation:	83 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:105980 Arnold JS, et al., Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
• All: 10 reference(s)