Tg(GFAP-TVA)10Ech
Transgene Detail

Summary

• Symbol: Tg(GFAP-TVA)10Ech
• Name: transgene insertion 10, Eric C Holland
• MGI ID: MGI:3619228
• Transgene: Tg(GFAP-TVA)10Ech Location: unknown
• Alliance: Tg(GFAP-TVA)10Ech page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene expresses TVA, the receptor for avian retrovirus ALV, subgroup A (ALV-A), from a quail cDNA under direction of a 2.2-kb promoter-containing fragment from the human glial fibrillary acidic protein, which confers specificity for terminally or near-terminally differentiated astrocytes. The construct also contains an intron and polyadenylation signal from the mouse protamine gene. Cells presenting this receptor can be infected by replication-competent ALV splice acceptor (RCAS) vectors, permitting cell type specific expression of vector-borne genes. (J:52161, J:69971)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:52161 Holland EC, et al., A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes Dev. 1998 Dec 1;12(23):3675-85
• All: 4 reference(s)