Gprc5a^tm1Jsx
Targeted Allele Detail

Summary

• Symbol: Gprc5a^tm1Jsx
• Name: G protein-coupled receptor, family C, group 5, member A; targeted mutation 1, Jingsong Xu
• MGI ID: MGI:3619232
• Synonyms: RAIG1^-
• Gene: Gprc5a Location: Chr6:135042660-135061707 bp, + strand Genetic Position: Chr6, 65.83 cM
• Alliance: Gprc5a^tm1Jsx page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:97487
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was designed such that 700 bp of coding sequence in exon 2 including the start codon was replaced with a lacZ-neo cassette. Northern blot failed to detect any endogenous transcript in mutant lungs. LacZ expression was detected in a pattern similar to the endogenous protein expression. (J:97487)

Expression

In Mice Carrying this Mutation:

34 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprc5a Mutation: 48 strains or lines available

References

• Original: J:97487 Xu J, et al., Normal Lung Development in RAIG1-Deficient Mice Despite Unique Lung Epithelium-Specific Expression. Am J Respir Cell Mol Biol. 2005 May;32(5):381-7
• All: 1 reference(s)