Kcnab1^tm1Mes
Targeted Allele Detail

Summary

• Symbol: Kcnab1^tm1Mes
• Name: potassium voltage-gated channel, shaker-related subfamily, beta member 1; targeted mutation 1, Albee Messing
• MGI ID: MGI:3619233
• Synonyms: KvBeta1.1 null
• Gene: Kcnab1 Location: Chr3:64856636-65285643 bp, + strand Genetic Position: Chr3, 30.15 cM
• Alliance: Kcnab1^tm1Mes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106453
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1a was replaced with a neomycin resistance cassette. The most abundant brain isoform was thus deleted while the primary heart isoform continued to be expressed. (J:106453)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnab1 Mutation: 27 strains or lines available

References

• Original: J:106453 Connor JX, et al., Genetic modifiers of the Kv beta2-null phenotype in mice. Genes Brain Behav. 2005 Mar;4(2):77-88
• All: 1 reference(s)