Bub3^tm1Jvd
Targeted Allele Detail

Summary

• Symbol: Bub3^tm1Jvd
• Name: BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
• MGI ID: MGI:3619247
• Synonyms: Bub3^-
• Gene: Bub3 Location: Chr7:131162081-131173625 bp, + strand Genetic Position: Chr7, 74.36 cM
• Alliance: Bub3^tm1Jvd page

Reduced lifespan, cataract, lordokyphosis and cachexia in Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81546
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was interrupted at amino acid 191 by homologous recombination. Exon 3 was replaced with a neomycin resistance gene in reverse orientation. Western blot detected the encoded protein in heterozygous mice at reduced levels. (J:81546)

Tumor Data

List all tumor models in MMHCdb carrying Bub3^tm1Jvd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bub3 Mutation: 23 strains or lines available

References

• Original: J:81546 Babu JR, et al., Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003 Feb 3;160(3):341-53
• All: 2 reference(s)