Ccng1^tm1Noj
Targeted Allele Detail

Summary

• Symbol: Ccng1^tm1Noj
• Name: cyclin G1; targeted mutation 1, Hiroshi Nojima
• MGI ID: MGI:3619512
• Gene: Ccng1 Location: Chr11:40639379-40646044 bp, - strand Genetic Position: Chr11, 24.42 cM, cytoband B1.1
• Alliance: Ccng1^tm1Noj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106744
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette replaced a part of the second exon. Mutant mice were subjected to 10 Gy gamma radiation and tissue lysates were analyzed by Western blot. Significant induction of cyclin G1 was observed in irradiated wild-type mice, but was not seen in tissues from cyclin G1 null mice. (J:106744)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccng1 Mutation: 20 strains or lines available

References

• Original: J:106744 Kimura SH, et al., Cyclin G1 is involved in G2/M arrest in response to DNA damage and in growth control after damage recovery. Oncogene. 2001 May 31;20(25):3290-300
• All: 2 reference(s)