Tollip^tm1Kbns
Targeted Allele Detail

Summary

• Symbol: Tollip^tm1Kbns
• Name: toll interacting protein; targeted mutation 1, Kimberly Burns
• MGI ID: MGI:3619521
• Synonyms: Tollip^-
• Gene: Tollip Location: Chr7:141435317-141456198 bp, - strand Genetic Position: Chr7, 87.34 cM, cytoband F5
• Alliance: Tollip^tm1Kbns page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105514
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced exon 1, which contains the start codon. (J:105514)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tollip Mutation: 21 strains or lines available

References

• Original: J:105514 Didierlaurent A, et al., Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol. 2006 Feb;26(3):735-42
• All: 16 reference(s)