Ing1^tm1Avg
Targeted Allele Detail

Summary

• Symbol: Ing1^tm1Avg
• Name: inhibitor of growth family, member 1; targeted mutation 1, A V Gudkov
• MGI ID: MGI:3619526
• Synonyms: ing1^-
• Gene: Ing1 Location: Chr8:11605762-11613251 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: Ing1^tm1Avg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105658
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 4, common to all transcripts and containing most of the protein coding sequences including the conserved PHD finger domain, with a neomycin resistance gene. Transcript was not detected in mutant MEFS in Northern blot analysis. Western blot failed to detect protein in mutants as well. (J:105658)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ing1 Mutation: 25 strains or lines available

References

• Original: J:105658 Kichina JV, et al., Targeted disruption of the mouse ing1 locus results in reduced body size, hypersensitivity to radiation and elevated incidence of lymphomas. Oncogene. 2006 Feb 9;25(6):857-66
• All: 2 reference(s)