Ryr2^tm1Amks
Targeted Allele Detail

Summary

• Symbol: Ryr2^tm1Amks
• Name: ryanodine receptor 2, cardiac; targeted mutation 1, Andrew R Marks
• MGI ID: MGI:3619529
• Synonyms: RyR2-S2808A
• Gene: Ryr2 Location: Chr13:11567988-12121831 bp, - strand Genetic Position: Chr13, 4.38 cM, cytoband A1-A2
• Alliance: Ryr2^tm1Amks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105666
• Parent Cell Line: MM13 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to insert an S2808A mutation into exon 55 by homologous recombination. A self-excising Cre recombinase with a testes-specific promoter, was removed from the locus upon passage through the germline. (J:105666)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ryr2 Mutation: 325 strains or lines available

References

• Original: J:105666 Wehrens XH, et al., Ryanodine receptor/calcium release channel PKA phosphorylation: a critical mediator of heart failure progression. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):511-8
• All: 9 reference(s)