Tbx1^tm2Bem
Targeted Allele Detail

Summary

• Symbol: Tbx1^tm2Bem
• Name: T-box 1; targeted mutation 2, Bernice E Morrow
• MGI ID: MGI:3619531
• Gene: Tbx1 Location: Chr16:18399729-18409412 bp, - strand Genetic Position: Chr16, Syntenic
• Alliance: Tbx1^tm2Bem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105980
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A Hygromycin-resistance cassette flanked by loxP sites was inserted between exons 3 and 4 along with a single loxP site between exons 1 and 2. The ATG is in exon 2. (J:105980)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx1 Mutation: 36 strains or lines available

References

• Original: J:105980 Arnold JS, et al., Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development. 2006 Mar;133(5):977-87
• All: 2 reference(s)