Lrp8tm4Her
Targeted Allele Detail
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| Symbol: |
Lrp8tm4Her |
| Name: |
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; targeted mutation 4, Joachim Herz |
| MGI ID: |
MGI:3619603 |
| Synonyms: |
Apoer2[Dab-], Apoer2 EIG |
| Gene: |
Lrp8 Location: Chr4:107659337-107734037 bp, + strand Genetic Position: Chr4, 50.18 cM, cytoband C7
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| Alliance: |
Lrp8tm4Her page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:105699
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Inserted expressed sequence) |
| Mutation: |
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Insertion
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Mutation details: A targeting vector was used to change an NFD amino acid sequence beginning at residue 893 to EIG (NFD893-895EIG), which disables the protein's ability to interact with Dab1. GST pull-down experiments confirmed the disruption of this interaction.
(J:105699)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Lrp8 Mutation: |
43 strains or lines available
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| Original: |
J:105699 Beffert U, et al., Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. J Neurosci. 2006 Feb 15;26(7):2041-52 |
| All: |
6 reference(s) |
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Analysis Tools
