Tg(Thy1-Ntrk2/EGFP)817Cnl
Transgene Detail

Summary

• Symbol: Tg(Thy1-Ntrk2/EGFP)817Cnl
• Name: transgene insertion 817, Christiaan N Levelt
• MGI ID: MGI:3619918
• Synonyms: TrkB.T1-EGFP
• Transgene: Tg(Thy1-Ntrk2/EGFP)817Cnl Location: unknown
• Alliance: Tg(Thy1-Ntrk2/EGFP)817Cnl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Dominant negative, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene consists of the Thy1 promoter followed by a loxP flanked stop signal and a truncated form of the murine Ntrk2 gene fused to EGFP. The truncated cDNA for Ntrk2 includes the region encoding amino acids 1-477 plus 74 bp of the 5' UTR. Cre mediated recombination removes the stop and allows expression of the fusion protein which functions as a dominant negative receptor. Seven founders were created however data for line 817 only were shown. (J:105706)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:105706 Chakravarthy S, et al., Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1071-6
• All: 3 reference(s)