Uros^tm2Cged
Targeted Allele Detail

Summary

• Symbol: Uros^tm2Cged
• Name: uroporphyrinogen III synthase; targeted mutation 1, Cecile Ged
• MGI ID: MGI:3620007
• Synonyms: Uros^del
• Gene: Uros Location: Chr7:133287972-133311801 bp, - strand Genetic Position: Chr7, 77.26 cM
• Alliance: Uros^tm2Cged page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107043
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene was inserted into the locus, replacing part of the coding sequence. The resulting transcript encodes a truncated protein of 204 amino acids instead of 265. (J:107043)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Uros Mutation: 18 strains or lines available

References

• Original: J:107043 Bensidhoum M, et al., The disruption of mouse uroporphyrinogen III synthase (uros) gene is fully lethal. Transgenics. 1998;2:275-280
• All: 2 reference(s)