S1pr3^tm1Rlp
Targeted Allele Detail

Summary

• Symbol: S1pr3^tm1Rlp
• Name: sphingosine-1-phosphate receptor 3; targeted mutation 1, Richard L Proia
• MGI ID: MGI:3620010
• Synonyms: S1P3-, S1pr3^-, S1pr3^tm1Cys
• Gene: S1pr3 Location: Chr13:51562675-51576833 bp, + strand Genetic Position: Chr13, 26.12 cM, cytoband B1
• Alliance: S1pr3^tm1Rlp page

Subcutaneous edema and thin endothelial cells in S1pr2^tm1Rlp/S1pr2^tm1Rlp S1pr3^tm1Rlp/S1pr3^tm1Rlp embryos

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106055
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of the coding sequence. Northern blot confirmed absence of transcript in mutant brain, heart and lung samples. (J:106055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any S1pr3 Mutation: 24 strains or lines available

References

• Original: J:106055 Kono M, et al., The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis. J Biol Chem. 2004 Jul 9;279(28):29367-73
• All: 33 reference(s)