Dpagt1^tm1Jxm
Targeted Allele Detail

Summary

• Symbol: Dpagt1^tm1Jxm
• Name: dolichyl-phosphate N-acetylglucosaminephosphotransferase 1; targeted mutation 1, Jamey Marth
• MGI ID: MGI:3620022
• Synonyms: GPT^delta
• Gene: Dpagt1 Location: Chr9:44237316-44245197 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Dpagt1^tm1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59695
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A single loxP site was inserted upstream of exon 1 and and additional loxP-flanked nemoycin/thymidine kinase selection cassette was inserted into intron 2. Transient cre expression in ES cells resulted in the deletion of all intervening sequences, including exons 1-2 and the selection cassette. Heterozygous mice exhibit a decrease in protein activity in livers and mammary gland. (J:59695)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpagt1 Mutation: 22 strains or lines available

References

• Original: J:59695 Marek KW, et al., A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality. Glycobiology. 1999 Nov;9(11):1263-71
• All: 1 reference(s)