Scd1^flk
Chemically induced Allele Detail

Summary

• Symbol: Scd1^flk
• Name: stearoyl-Coenzyme A desaturase 1; flake
• MGI ID: MGI:3620028
• Synonyms: scd1^m1Btlr
• Gene: Scd1 Location: Chr19:44382889-44396148 bp, - strand Genetic Position: Chr19, 37.98 cM
• Alliance: Scd1^flk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation was identified in a screen of progeny of ENU mutagenized male mice for immunologic phenotypes. It is a C-to-A transversion in exon 5 (at nucleotide position 938 of cDNA sequence NCBI BC055453) that causes replacement of the neutral amino acid threonine with a charged lysine residue (T227K) in the fourth of six transmembrane domains. (J:100424)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Scd1 Mutation: 24 strains or lines available

References

• Original: J:100424 Georgel P, et al., A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria. Infect Immun. 2005 Aug;73(8):4512-21
• All: 1 reference(s)