Mylk^tm1Avs
Targeted Allele Detail

Summary

• Symbol: Mylk^tm1Avs
• Name: myosin, light polypeptide kinase; targeted mutation 1, A V Somlyo
• MGI ID: MGI:3620051
• Gene: Mylk Location: Chr16:34565580-34822790 bp, + strand Genetic Position: Chr16, 24.49 cM
• Alliance: Mylk^tm1Avs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106058
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEvBrd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A targeting vector was designed to remove a 30-nucleotide promoter sequence containing the AT-rich region and the CArG box, resulting in a complete loss of protein. (J:106058)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mylk Mutation: 103 strains or lines available

References

• Original: J:106058 Khromov AS, et al., Smooth muscle of telokin-deficient mice exhibits increased sensitivity to Ca2+ and decreased cGMP-induced relaxation. Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2440-5
• All: 3 reference(s)