Mstn^tm1.1Swel
Targeted Allele Detail

Summary

• Symbol: Mstn^tm1.1Swel
• Name: myostatin; targeted mutation 1.1, Stephen Welle
• MGI ID: MGI:3620058
• Synonyms: Mstn^deltaE3
• Gene: Mstn Location: Chr1:53100799-53107238 bp, + strand Genetic Position: Chr1, 26.99 cM
• Alliance: Mstn^tm1.1Swel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106054
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3, which encodes the entire active portion of the peptide, was removed via cre mediated recombination. (J:106054)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mstn Mutation: 34 strains or lines available

References

• Original: J:106054 Welle S, et al., Myofibrillar protein synthesis in myostatin-deficient mice. Am J Physiol Endocrinol Metab. 2006 Mar;290(3):E409-15
• All: 3 reference(s)