Fgfr1^tm5.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm5.1Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 5.1, Philippe Soriano
• MGI ID: MGI:3620060
• Synonyms: Fgfr1^cKO, Fgfr1^floxex4
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm5.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105920
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 4 was flanked by loxP sites via homologous recombination. Exon 4 is the first allele common to all splice variants. The Neo selection cassette was removed by Flp-mediated excision by breeding to FlpeR mice. (J:105920)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:105920 Hoch RV, et al., Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development. 2006 Feb;133(4):663-73
• All: 20 reference(s)