Fgfr1^tm5.2Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr1^tm5.2Sor
• Name: fibroblast growth factor receptor 1; targeted mutation 5.2, Philippe Soriano
• MGI ID: MGI:3620061
• Synonyms: Fgfr1^-, Fgfr^deltaex4
• Gene: Fgfr1 Location: Chr8:26008808-26067819 bp, + strand Genetic Position: Chr8, 14.12 cM
• Alliance: Fgfr1^tm5.2Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105920
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 4 was flanked by loxP sites via homologous recombination. Exon 4 is the first allele common to all splice variants. Cre-mediated excision of exon 4 was accomplished by breeding to a Cre-expressing line. (J:105920)

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fgfr1 Mutation: 223 strains or lines available

References

• Original: J:105920 Hoch RV, et al., Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development. Development. 2006 Feb;133(4):663-73
• All: 3 reference(s)