Ikbkg^tm1Mka
Targeted Allele Detail

Summary

• Symbol: Ikbkg^tm1Mka
• Name: inhibitor of kappaB kinase gamma; targeted mutation 1, Michael Karin
• MGI ID: MGI:3620102
• Synonyms: Ikkgamma^-, NEMO^-
• Gene: Ikbkg Location: ChrX:73436896-73497460 bp, + strand Genetic Position: ChrX, 38.0 cM
• Alliance: Ikbkg^tm1Mka page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63054
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: This allele was created by using one of two vectors. The first vector was designed to insert a beta-lactamase cassette, a stop codon and a neomycin resistance gene in frame with the first ten codons. The second vector was designed to remove most of the coding sequence in the first exon and replace it with a beta-lactamase and neomycin resistance cassette. Western blot failed to detect protein in mutant ES cells. (J:63054)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikbkg Mutation: 16 strains or lines available

References

• Original: J:63054 Makris C, et al., Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell. 2000 Jun;5(6):969-79
• All: 2 reference(s)