Aia1^NZC/Omr
QTL Variant Detail

Summary

• QTL variant: Aia1^NZC/Omr
• Name: autoimmune hemolytic anemia 1; NZC/Omr
• MGI ID: MGI:3620161
• QTL: Aia1 Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: NZC/Omr

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6517

A locus associated with autoimmune hemolytic anemia was mapped to mouse Chromosome 4 using 100 (NZB/Omr x NZC/Omr)F1 x NZB/Omr and 180 (NZB/Omr x NZC/Omr)F1 x NZC/Omr backcross animals. Parental strain NZB/Omr is highly susceptible (nearly 100% incidence) to spontaneous autoimmune hemolytic anemia compared to parental strain NZC/Omr (0% incidence). Aia1 (autoimmune hemolytic anemia 1) is approximately 36 cM away from Tryp1 (previously known as the coat color gene b), and thought to be located near the minor histocompatibility locus H18 (74.5 cM), a potential candidate gene. Susceptibility to hemolytic autoimmune anemia is derived from the NZB/Omr allele at Aia1. A second unmapped locus, Aia2, is thought to exist. Aia1 and Aia2 are thought to exhibit a dominant or co-dominant effect.

References

• Original: J:6517 Knight JG, et al., Genes determining autoimmune disease in New Zealand mice. J Clin Lab Immunol. 1981 May;5(3):165-70
• All: 1 reference(s)