Ads4^NZW
QTL Variant Detail

Summary

• QTL variant: Ads4^NZW
• Name: anti dsDNA antibody 4; NZW
• MGI ID: MGI:3620174
• QTL: Ads4 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: NZW

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased conversion of IgM to IgG antibodies compared to NZB. (J:7111)
• Inheritance: Dominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ads4^NZW/Ads4^NZW	involves: NZB * NZW
ht2	Ads4^NZB/Ads4^NZW	involves: NZB * NZW

Phenotypes:

Affected Systems	hm1	ht2
show or hide all annotated terms
hematopoietic system	√	√
abnormal immunoglobulin level	√	√
immune system	√	√
abnormal immunoglobulin level	√	√
increased susceptibility to autoimmune disorder	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:11074

NZB/Slc animals develop autoimmune phenotypes similar to human lupus nephritis, such as proteinuria and production of anti-histone and anti-DNA autoantibodies. The NZW/Slc strain does not develop autoimmune disease. NZW.NZB-Tcrb, a congenic line derived from NZB/Slc donor DNA at the Tcrb locus (20.5 cM) on mouse Chromosome 6 on a NZW/Slc genetic background, were crossed to the susceptible NZB/Slc parent. (NZW.NZB-Tcrb x NZB/Slc)F1 animals exhibit decreased anti-dsDNA antibodies and decreased proteinuria incidence compared to (NZB/Slc x NZW/Slc)F1 animals. A locus named Ads4 (anti dsDNA antibody 4) is thought to reside within the Tcrb-linked congenic interval.

References

• Original: J:7111 Hirose S, et al., Enhancing effect of H-2-linked NZW gene(s) on the autoimmune traits of (NZB X NZW)F1 mice. J Exp Med. 1983 Jul 1;158(1):228-33
• All: 2 reference(s)