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Agp2NZW
QTL Variant Detail
Summary
QTL variant: Agp2NZW
Name: anti gp70 immune complex 2; NZW
MGI ID: MGI:3620208
QTL: Agp2  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  NZW
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers increased anti-gp70 immune complex formation compared to NZB. (J:6920)
Inheritance:    Dominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
Agp2 may act in concert with Agp1 to intensify anti-gp70 immune complex formation.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6920

Inbred strain NZB spontaneously develops autoantibodies and glomerulonephritis similar to human lupus nephritis, whereas inbred strain NZW does not. Analysis of 123 (NZB x NZW)F1 x NZW and 113 (NZB x NZW)F1 x NZB female backcross animals reveal 2 dominant H2- linked loci associated with anti-gp70 immune complex formation. Agp1 (anti gp70 immune complex 1) is derived from the NZB genetic background whereas Agp2 (anti gp70 immune complex 2) is derived from the NZW genetic background. Loose linkage between Agp1 and H2 is estimated at 25.2 cM. The location of Agp2 is estimated to be approximately 31 cM from H2. Agp2 may act to intensify formation of gp70 immune complexes in concert with Agp1. A separate unlinked and yet unidentified locus affecting the magnitude of gp70 immune complex formation was hypothesized to exist.

References
Original:  J:6920 Maruyama N, et al., Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease. J Immunol. 1983 Feb;130(2):740-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory