Agp2^NZW
QTL Variant Detail

Summary

• QTL variant: Agp2^NZW
• Name: anti gp70 immune complex 2; NZW
• MGI ID: MGI:3620208
• QTL: Agp2 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: NZW

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased anti-gp70 immune complex formation compared to NZB. (J:6920)
• Inheritance: Dominant

Notes

Agp2 may act in concert with Agp1 to intensify anti-gp70 immune complex formation.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6920

Inbred strain NZB spontaneously develops autoantibodies and glomerulonephritis similar to human lupus nephritis, whereas inbred strain NZW does not. Analysis of 123 (NZB x NZW)F1 x NZW and 113 (NZB x NZW)F1 x NZB female backcross animals reveal 2 dominant H2- linked loci associated with anti-gp70 immune complex formation. Agp1 (anti gp70 immune complex 1) is derived from the NZB genetic background whereas Agp2 (anti gp70 immune complex 2) is derived from the NZW genetic background. Loose linkage between Agp1 and H2 is estimated at 25.2 cM. The location of Agp2 is estimated to be approximately 31 cM from H2. Agp2 may act to intensify formation of gp70 immune complexes in concert with Agp1. A separate unlinked and yet unidentified locus affecting the magnitude of gp70 immune complex formation was hypothesized to exist.

References

• Original: J:6920 Maruyama N, et al., Genetic studies of autoimmunity in New Zealand mice. IV. Contribution of NZB and NZW genes to the spontaneous occurrence of retroviral gp70 immune complexes in (NZB X NZW)F1 hybrid and the correlation to renal disease. J Immunol. 1983 Feb;130(2):740-6
• All: 1 reference(s)