Naip1^tm1Aem
Targeted Allele Detail

Summary

• Symbol: Naip1^tm1Aem
• Name: NLR family, apoptosis inhibitory protein 1; targeted mutation 1, Alex E MacKenzie
• MGI ID: MGI:3620316
• Synonyms: Birc1a^-, Naip1^-
• Gene: Naip1 Location: Chr13:100544272-100589372 bp, - strand Genetic Position: Chr13, 53.18 cM, cytoband D1-D3
• Alliance: Naip1^tm1Aem page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:60925
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ and PGK-neo was inserted to replace exons 2 and 3. RT-PCR failed to detect transcript in mutants. (J:60925)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Naip1^tm1Aem/Naip1^tm1Aem	129X1/SvJ-Naip1^tm1Aem

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms
cellular	√
increased susceptibility to neuronal excitotoxicity	√
homeostasis/metabolism	√
increased susceptibility to neuronal excitotoxicity	√
nervous system	√
increased susceptibility to neuronal excitotoxicity	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naip1 Mutation: 78 strains or lines available

References

• Original: J:60925 Holcik M, et al., The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury. Proc Natl Acad Sci U S A. 2000 Feb 29;97(5):2286-90
• All: 2 reference(s)