Slc18a2^tm1Uhl
Targeted Allele Detail

Summary

• Symbol: Slc18a2^tm1Uhl
• Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, George R Uhl
• MGI ID: MGI:3620458
• Synonyms: VMAT2^-
• Gene: Slc18a2 Location: Chr19:59249328-59284444 bp, + strand Genetic Position: Chr19, 54.64 cM
• Alliance: Slc18a2^tm1Uhl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42811
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion A genomic fragment containing exons 1-3 was replaced with a neomycin selection cassette. (J:42811)

Construction and characterization of VMAT2 knockout mice.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc18a2 Mutation: 29 strains or lines available

References

• Original: J:42811 Takahashi N, et al., VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9938-43
• All: 6 reference(s)