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Slc18a2tm1Uhl
Targeted Allele Detail
Summary
Symbol: Slc18a2tm1Uhl
Name: solute carrier family 18 (vesicular monoamine), member 2; targeted mutation 1, George R Uhl
MGI ID: MGI:3620458
Synonyms: VMAT2-
Gene: Slc18a2  Location: Chr19:59249328-59284444 bp, + strand  Genetic Position: Chr19, 54.64 cM
Alliance: Slc18a2tm1Uhl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42811
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A genomic fragment containing exons 1-3 was replaced with a neomycin selection cassette. (J:42811)
Construction and characterization of VMAT2 knockout mice.
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc18a2 Mutation:  29 strains or lines available
References
Original:  J:42811 Takahashi N, et al., VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity. Proc Natl Acad Sci U S A. 1997 Sep 2;94(18):9938-43
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory