Akap1^tm1Gsm
Targeted Allele Detail

Summary

• Symbol: Akap1^tm1Gsm
• Name: A kinase anchor protein 1; targeted mutation 1, G Stanley McKnight
• MGI ID: MGI:3620561
• Gene: Akap1 Location: Chr11:88721618-88755412 bp, - strand Genetic Position: Chr11, 54.34 cM
• Alliance: Akap1^tm1Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106320
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exon 2, which encodes the majority of the protein in all splice variants. Western blot confirmed that all variants were absent in mutant tissues including ovary. (J:106320)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Akap1 Mutation: 64 strains or lines available

References

• Original: J:106320 Newhall KJ, et al., Dynamic anchoring of PKA is essential during oocyte maturation. Curr Biol. 2006 Feb 7;16(3):321-7
• All: 7 reference(s)