Lyst^bg-grey
Chemically induced Allele Detail

Summary

• Symbol: Lyst^bg-grey
• Name: lysosomal trafficking regulator; beige grey
• MGI ID: MGI:3620573
• Gene: Lyst Location: Chr13:13764982-13953388 bp, + strand Genetic Position: Chr13, 5.28 cM
• Alliance: Lyst^bg-grey page

Morphologic investigation of Lyst^bg-grey/Lyst^bg-grey and +/+ wild-type mice.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: A point mutation of the splice donor site of the intron between exon 25 and exon 26 caused skipping of exon 25 during RNA splicing without disrupting the reading frame. The resulting transcript has a 77 residue deletion. (J:106442)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyst Mutation: 225 strains or lines available

References

• Original: J:106442 Runkel F, et al., Grey, a novel mutation in the murine Lyst gene, causes the beige phenotype by skipping of exon 25. Mamm Genome. 2006 Mar;17(3):203-10
• All: 1 reference(s)