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Gja1tm6.1(Gjb3)Kwi
Targeted Allele Detail
Summary
Symbol: Gja1tm6.1(Gjb3)Kwi
Name: gap junction protein, alpha 1; targeted mutation 6.1, Klaus Willecke
MGI ID: MGI:3620584
Synonyms: Cx4331
Gene: Gja1  Location: Chr10:56253297-56266519 bp, + strand  Genetic Position: Chr10, 28.64 cM
Alliance: Gja1tm6.1(Gjb3)Kwi page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:106509
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprt1b-m3
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutation:    Insertion
 
Mutation detailsCrossing mice bearing Gja1tm6(Gjb3)Kwi with mice expressing Cre recombinase in the germline resulted in excision of the coding region of Gja1, placing that of Gja3, which had been inserted between the Gja1 termination codon and its downstream DNA, under control of the Gja1 regulatory sequences. Immunoblot analysis demonstrates the absence of GJA1 protein and the presence of GJA3 protein, at dosage dependent levels, in lysates of heart and brain from mice bearing this allele. (J:106509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gja1 Mutation:  60 strains or lines available
References
Original:  J:106509 Zheng-Fischhofer Q, et al., Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice. J Cell Sci. 2006 Feb 15;119(Pt 4):693-701
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory