Plod3^tm1Rmyl
Targeted Allele Detail

Summary

• Symbol: Plod3^tm1Rmyl
• Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; targeted mutation 1, Raili Myllyla
• MGI ID: MGI:3620600
• Synonyms: LH3 knock-out
• Gene: Plod3 Location: Chr5:137015873-137025500 bp, + strand Genetic Position: Chr5, 76.09 cM
• Alliance: Plod3^tm1Rmyl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106510
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of an IRES-beta-gal-polyA-neo cassette into exon 2 disrupted the locus. Absence of transcript was confirmed by Northern blot. (J:106510)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plod3 Mutation: 60 strains or lines available

References

• Original: J:106510 Ruotsalainen H, et al., Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes. J Cell Sci. 2006 Feb 15;119(Pt 4):625-35
• All: 5 reference(s)