Lmna^tm2Lgf
Targeted Allele Detail

Summary

• Symbol: Lmna^tm2Lgf
• Name: lamin A; targeted mutation 2, Loren G Fong
• MGI ID: MGI:3620627
• Synonyms: Lmna^LCO
• Gene: Lmna Location: Chr3:88388455-88413842 bp, - strand Genetic Position: Chr3, 38.84 cM
• Alliance: Lmna^tm2Lgf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to delete the last 150 nucleotides of exon 11 and all of intron 11. The deletion created an in-frame fusion between codon 608 in exon 11 and codon 659 in exon 12. A floxed neo included in the vector was removed via cre-mediated recombination. Northern and Western blot demonstrated that no lamin A was produced. Lamin C was produced at wild-type levels. (J:106473)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lmna Mutation: 84 strains or lines available

References

• Original: J:106473 Fong LG, et al., Prelamin A and lamin A appear to be dispensable in the nuclear lamina. J Clin Invest. 2006 Mar;116(3):743-52
• All: 5 reference(s)