Ppp1r1b^tm1Pggd
Targeted Allele Detail

Summary

• Symbol: Ppp1r1b^tm1Pggd
• Name: protein phosphatase 1, regulatory inhibitor subunit 1B; targeted mutation 1, Paul Greengard
• MGI ID: MGI:3620646
• Synonyms: A34T, DARPP-32 T34A, T34A-DARPP-32, Thr³⁴-DARPP-32
• Gene: Ppp1r1b Location: Chr11:98239232-98248622 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Ppp1r1b^tm1Pggd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:107305
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Mutation details: Threonine 34 was replaced with an alanine to prevent phosphorylation. Immunoblot confirmed presence of the mutation. A neomycin resistance cassette included in the targeting construct was deleted via cre-mediated recombination. (J:107305)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppp1r1b Mutation: 18 strains or lines available

References

• Original: J:107305 Svenningsson P, et al., Diverse psychotomimetics act through a common signaling pathway. Science. 2003 Nov 21;302(5649):1412-5
• All: 16 reference(s)