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Rr149356tm1Che
Targeted Allele Detail
Summary
Symbol: Rr149356tm1Che
Name: regulatory region 149356; targeted mutation 1, Jianzhu Chen
MGI ID: MGI:3620665
Synonyms: EbetaR
Gene: Rr149356  Location: Chr6:41526801-41532817 bp, . strand  Genetic Position: Chr6, Syntenic
Alliance: Rr149356tm1Che page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:107306
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA concatamer of 8 copies of the Lgals4 binding sequence replaced 560 bp of the locus to inactivate the enhancer and to allow opportunitites to target heterologous proteins to the locus. A floxed neo cassette included in the vector was deleted by cre-mediated excision. (J:107306)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr149356 Mutation:  0 strains or lines available
References
Original:  J:107306 Ryu CJ, et al., The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13465-70
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory